Also, keep in mind that if your anemia is causing certain symptoms, treatment with Injectafer may help those symptoms go away. Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. fever. Allergic reaction As with most drugs, some people can have an allergic reaction after taking Injectafer. There are currently no generic forms of either drug. The insurance company will review the prior authorization request and decide if the drug will be covered. Throw away unused or expired drugs. You may report side effects to FDA at 1-800-FDA-1088. And this type of reaction is possible even if you didnt have a reaction to your first dose of the drug. <> Other drugs are available that can treat iron deficiency anemia (IDA). I can't take oral supplements because they cause horrible debilitating Constipation. This medication passes into breast milk. Potentialside effectsthat are usually mild may include, but are not limitedto: Theseside effectsmay not impact life too much and may only be temporary. They can tell you about other medications that may work well for you. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. What to know about iron deficiency anemia, took oral iron treatment and didnt have improvement in their IDA or had side effects that couldnt be managed, or, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your tongue, mouth, or throat, have a medical condition that affects their bodys ability to absorb phosphorus, take medications that affect how well their, ferrous sulfate (Fer-Iron, Slow-FE, Feosol), people who took Injectafer had their hemoglobin level increase by an average of 1.1 grams per deciliter (g/dL), people who took Venofer had their hemoglobin increase by an average of 0.9 g/dL. Do not share your drugs with others and do not take anyone else's drugs. The Food and Drug Administration (FDA) approves prescription drugs such as Injectafer to treat certain conditions. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. So you wont pick up this medication from a pharmacy. (Hemoglobin is a protein thats found inside your red blood cells.). US residents can call their local poison control center at 1-800-222-1222. Before approving coverage for Injectafer, your insurance company may require you to get prior authorization. Last updated on Feb 20, 2023. Very bad and sometimes deadly allergic side effects have rarely happened. Patients should induce vomiting or evacuate the stomach by lavage during Venofer overdoasge. Venofer may cause serious side effects including: problems with your dialysis vein access point, chest pain, severe headache, blurred vision, pounding in your neck or ears, lightheadedness, pain or swelling, bloating, nausea, vomiting, loss of appetite, diarrhea, and fever Get medical help right away, if you have any of the symptoms listed above. With IV infusion, the drug is given as a slow drip into your vein over a period of time. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. For instance, someone with lowblood pressuremay receive a medication to prevent migraines that lowersblood pressure, this may causeseriousside effects. You may also need to monitor your blood pressure at home. The benefit of treating your condition during pregnancy may outweigh any risks. Your doctor will do laboratory tests to monitor your response. With this condition, you also have a low hemoglobin level. Your doctor will recommend whether you should stop taking your multivitamin or any other supplements. These tests will help make sure Injectafer is working to treat your iron deficiency anemia (IDA). Injectafer can be exposed to temperatures between 59F to 86F (15C to 30F) for a short period of time. These pregnancy-related problems include preterm delivery and low birth weight of your infant. If you have symptoms of a low phosphorus level, call your doctor. Use Venofer as ordered by your doctor. Pain, swelling, or redness at the injection site may occur. If you come into contact with Red Tide, it can cause respiratory irritation, coughing, and sneezing. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. Otherwise, call a poison control center right away. This way, if you have an allergic reaction to Injectafer, your healthcare professional can treat your reaction. treatment schedule in further detail. For example, some people with anemia have extreme fatigue (lack of energy), which can make it hard for them to exercise. But its only approved for use in people with CKD who may or may not need dialysis. Iron is a vital mineral in the body, central to transporting oxygen around the body in the hemoglobin. The researchers looked to see how well each drug worked to increase peoples hemoglobin level. And babies born to those who took Injectafer during pregnancy didnt have any major congenital anomalies (also sometimes called birth defects). However, diarrhea it isnt very common in people using Injectafer. pain or burning at the injection site. Its important to note that youll get Injectafer doses from a doctor or healthcare professional in a medical facility. Do not flush down a toilet or pour down a drain unless you are told to do so. dizziness. If you have diarrhea while youre taking Injectafer, call your doctor. But the length of time that this may take varies from person to person. People who are ongoingcancer treatmentwithradiation therapyor takingchemotherapy drugsmay be more susceptible toside effects. Sharing this information can help you avoid potential interactions. How is Venofer (iron sucrose) given? Before using iron sucrose, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. If you do breastfeed while youre taking Injectafer, the drugs manufacturer recommends that you monitor your child for side effects of the drug. cough. With IDA, you have low hemoglobin levels. endobj If you have iron deficiency anemia (IDA), consuming moderate amounts of alcohol may be safe, if your doctor tells you its OK. (With IDA, you have a low level of red blood cells thats caused by not having enough iron.). People from different ethnic backgrounds process medications differently. This is because alcohol reduces your bodys absorption of certain nutrients that are necessary to make red blood cells. Symptoms of a severe allergic reaction can include: Because of the risk of allergic reaction with Injectafer, your healthcare professional will monitor you for at least 30 minutes after you get each dose of the drug. For more information about taking Injectafer during pregnancy, see the section Injectafer and pregnancy above. There isnt a known interaction between Injectafer and alcohol. Many people believe they are suffering fromside effectsand may actually be suffering from anothermedical condition, such as havingdifficulty breathingorshortness of breath, which could be a heartattack. For instance, those who are taking other medications or supplements as part of home remedies may continue to suffer from the ill effects of their new medication because they dontinteract. Weight influences how fast medication breaks down in the body, so it also affects how longside effectswill last. 2 0 obj Once you have waited for 30 minutes after the injection, you may go home, providing you are feeling well. In fact, Injectafer is meant for some people whose anemia didnt improve with iron pills or for people who had side effects from iron pills. With slow IV injection, the drug is given as a single, slow injection into your vein. Precautions. fever, cold or flu symptoms (sore throat, cough, stuffy nose, sneezing); bruising or irritation where the medicine was injected. Potential injection site discoloration has happened. Your dosage and length of treatment are based on your medical condition, age, and response to treatment. If youre concerned about weight changes while youre taking Injectafer, talk with your doctor. Iron sucrose can harm an unborn baby if you have a severe reaction to this medicine during your second or third trimester. If a person does not have an allergic response or any other unanticipated reactions, a doctor will administer the remaining iron. If youre interested in finding an alternative to Injectafer, talk with your doctor. pain in the arms or legs. Dizziness. If this happens to you, your doctor may recommend that you receive another treatment course of Injectafer. You may report side effects to the FDA at 1-800-332-1088. But they wont receive a total cumulative dose of more than 1,500 mg of Injectafer. Injectafer contains the active drug ferric carboxymaltose, while Feraheme contains the active drug ferumoxytol. For reasons we dont fully understand, some peoples immune system gets over-activated when the drug enters their body. To learn about other mild side effects, talk with your doctor or pharmacist, or see Injectafers package insert. Additional studies are ongoing to see if Injectafer is a safe and effective treatment option for these conditions. upper respiratory infection. In this study, researchers compared Feraheme treatment with that of ferric carboxymaltose (the active drug in Injectafer). In clinical trials, pregnant females* who took Injectafer didnt have any negative outcomes, such as premature delivery or pregnancy loss. This product may contain inactive ingredients, which can cause allergic reactions or other problems. You may report side effects to the FDA at 1-800-332-1088. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. But for most people whove developed hypophosphatemia with Injectafer, the condition resolved within 3 months. Discuss the risks and benefits with your doctor. This is why family members often have the same issues with drugs as others in theirfamily. Follow your doctor's directions carefully. In one study, treatment with Injectafer was compared with that of iron thats taken by mouth. In clinical trials,. However, consuming large amounts of alcohol can actually cause anemia in some people. Venofer pregnancy and breastfeeding warnings. Iron-refractory iron deficiency anemia (IRIDA) is a genetic form of anemia. chills difficulty with moving ear congestion or pain flushed, dry skin fruit-like breath odor increased hunger or thirst increased urination lack or loss of strength pain or redness at the injection site pale skin at the injection site runny nose, sneezing sore throat unexplained weight loss Rare Burning, dry, or itching eyes Together, you and your doctor can develop a treatment plan thats best for you. In the studies, peoples hemoglobin level was measured to check for improvement in their anemia. stream And this can affect how well those parts of your body are able to work. Theyll likely have you stop taking the pills while youre using Injectafer. Others last much longer (even a lifetime), which can be quite traumatizing to people. Injectafer infusions are given over a period of at least 15 minutes. Note: The Food and Drug Administration (FDA) tracks side effects of drugs they have approved. Usually, when drugs may cause an immune system reaction like this, its a concern with your first dose of the drug. Consult your doctor before breast-feeding. Injectafer may not be right for you if you have certain medical conditions or other factors affecting your health. It may also cause nervousness, restlessness, and difficulty sleeping in some people. During Injectafer treatment, your doctor will likely order blood tests. Dr. Brandon ColbyMDis a US physician specializingin the personalized prevention of disease through the use of genomic technologies. Version: 7.01. To help make sure that you dont miss an appointment for your Injectafer dose, try setting an appointment reminder on your phone. What to Expect When You Get Your Whole Genome Sequenced, DNA Data Can Help You Understand Ehlers-Danlos Syndrome (EDS). This gives a total cumulative dose of 1,500 mg of Injectafer. Some people only need one treatment course of Injectafer. Other side effects include: Common (may affect up to 1 in 10 users) Temporary taste changes (especially metallic taste) Low blood pressure or high blood pressure. This is a sudden response affecting the entire body, which sometimes happens to people who are allergic to peanuts or beestings. Or your doctor may recommend that you change your eating habits to include more iron in your diet. These lists contain examples of serious side effects that can occur with Injectafer, with Venofer, or with both drugs (when taken individually). If you have a severe allergic reaction to Injectafer after youve left the medical facility where you received your dose of the drug, call your doctor right away. Many patients with kidney disease cannot get enough iron from food and require injections. Review our medical disclaimer. Venofer and the Venofer logo are registered trademarks of Vifor (International) Inc., Switzerland. Hemoglobin is a protein thats found in your RBCs. With IDA, you have anemia (low red blood cell level) thats due to not having enough iron in your body. Since someallergic reactionscan belife-threatening, its essential to discuss any adverse events previously experienced with the prescribingphysician. Venofer is manufactured under license from Vifor (International) Inc., Switzerland. Keep in mind that there may be additional costs related to getting your doses of the drug at a medical facility. Keep out of reach of children. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. In pediatric patients the most common side effects (>2%) are headache, viral respiratory tract infection, peritonitis, upset stomach, throwing up, fever, dizziness, cough, arteriovenous fistula thrombosis, hypotension and hypertension (increased blood pressure). But you dont necessarily need to eat these foods unless your doctor tells you to do so. Total cumulative Venofer dose = number of 100mg ampoules for Hb increase. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. This document does not contain all possible drug interactions. The Injectafer dosage your doctor prescribes will depend on your body weight. 5 0 obj Tell your doctor if you are taking iron supplements or other iron-based oral medications, such as: This list is not complete. In the US - Call your doctor for medical advice about side effects. It depends. Constipation,dry mouth, headaches, upset stomach, and many othercommonside effectscan greatly affect peoples quality of life, though. SIDE EFFECTS: Muscle cramps, nausea, vomiting, strange taste in the mouth, diarrhea, constipation, headache, cough, back pain, joint pain, dizziness, or swelling of the arms/legs may occur. No, you dont need to follow a specific diet plan while youre using Injectafer unless your doctor recommends otherwise. Dizziness. Depending on your anemia symptoms, your weight changes may be different than those described here. Iron sucrose can also be mixed in a. Dr. Colby holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford Universitys Graduate School of Business, and a degree in Genetics with Honors from the University of Michigan. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. An example of a drug interaction that many people are not aware of isgrapefruitjuice and statins. Both of theseside effectscould worsen depression and lead tolife-threateningconsequences. In clinical studies, people who took Injectafer still had iron in their system that was released by the drug 24 days after theyd gotten their injection. Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. If you have questions about using Injectafer in a child, talk with your doctor. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. All rights reserved. Hypophosphatemia risk appears to be substantially lower with other IV iron formulations. Source: Wolters Kluwer Health. A lack of iron can lead to iron deficiency anaemia if left untreated. How long it takes for the bodyto break down the meds matters and some peoples bodies simply take longer than others. Venofer may reduce the absorption of iron preparations taken by mouth. Venofer® (iron sucrose injection, USP) is available by prescription only. TheNational Instituteof Health (NIH) and the U.S.Food and Drug Administration(FDA) monitor the side effectsof new and approved medications to ensure safety. It can also cause skin irritation and redness. You should not be treated with this medicine if you have ever had an allergic reaction to an iron injection. You are encouraged to report side effects to American Regent, Inc. at 1-800-734-9236 or to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088. Venofer (iron sucrose injection, USP) is indicated for the treatment of iron deficiency anemia (IDA) in adult and pediatric (2 years of age and older) patients with chronic kidney disease (CKD), and is administered only by or under the supervision of your healthcare provider. In one study, people were given either Injectafer or an iron replacement drug called Venofer. I had my first infusion of 1gm 10 days ago. fruit-like breath odor increased hunger or thirst increased urination lack or loss of strength pain or redness at the injection site pale skin at the injection site runny nose, sneezing sore throat unexplained weight loss Rare Burning, dry, or itching eyes discharge or excessive tearing Copyright 1996-2023 Cerner Multum, Inc. Low iron saturation, or iron deficiency, has various possible causes. Iron sucrose injection has a molecular weight of approximately 34,000 - 60,000 daltons and a proposed structural formula: This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction. If you are using this medication at home, learn all preparation and usage instructions from your health care professional. Side effects: DayQuil can cause side effects such as drowsiness, dizziness, nausea, vomiting, and stomach upset. *Patients are calculated based on an estimated annual cumulative dose. Learn about the causes, symptoms, diagnosis, and treatment of this. In the second group, some people switched from taking iron by mouth to taking Injectafer. Daiichi Sankyo, Inc., the manufacturer of Injectafer, offers a program called injectconnect, which may help lower the cost of the drug. Venofer (iron sucrose) is given by injection into a vein as directed by your doctor. <> If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. This is why they have a programcalledMedWatchthat encourages Americans to report adversereactions. . You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. Injectafer and Feraheme have different approved uses, but theyre both used to treat IDA in certain adults. Back pain. Drug class: Iron products. Patients with celiac disease (gluten intolerance). Hemoglobin is a protein thats found inside your red blood cells. Infusion times range from less than 20 minutes to up to 4 hours. You will need to talk about the benefits and risks to you and the baby. Headache. Iron infusions are given directly into a vein. Injectafer isnt a medication that youll take regularly on a schedule. They have been a god send. These are not all of the side effects that may occur. This includes your doctors, nurses, pharmacists, and dentists. These side effects may include constipation and diarrhea. Potential side effects that are usually mild may include, but are not limited to: Headache Nausea Dry Mouth Stomachache Dizziness Diarrhea Constipation These side effects may not impact life too much and may only be temporary. This treatment course is split into two doses of the drug, which are given at least 7 days apart. Most of these side effects may go away within a few days or a couple of weeks. People with IDA have low blood levels of hemoglobin. These lists dont include all possible side effects. Laboratory tests (such as complete blood count, ferritin, transferrin, total iron binding capacity-TIBC) should be performed periodically to monitor your progress or check for side effects. After the infusion, you can drive yourself home and return to your usual activities. The study also didnt show if one treatment was worse than the other. What is the latest research on the form of cancer Jimmy Carter has? Innovators Monograph Your doctor will be able to see how Venofer is working by reviewing your blood tests. This survey is being conducted by the WebMD marketing sciences department. However, since peoples bodies react so differently to drugs, they often have to change their stance on certain drugs. You may wonder how Injectafer compares with other medications that are prescribed for similar uses. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. <> 2023 Medicine.com All rights reserved. These lists contain up to 10 of the most common mild side effects that can occur with Injectafer, with Feraheme, or with both drugs (when taken individually). For people weighing 50 kg (about 110 lb) or more, administer Injectafer in two doses of 750 mg, at least 7 days apart. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. And theyll recommend how soon after starting the drug you need to have this level checked. And these two doses need to be separated by at least 7 days. As a result, you may not make as much EPO as usual. For some people, it may be OK to continue taking a multivitamin that contains iron. Venofer also comes as a liquid thats given by either IV infusion or a slow IV injection. (A medication class is a group of medications that work in a similar way.). Orofer S 100 Injection 1 Injection in 1 Packet 286 301 5% off. Your body may also need more iron if you use the drug erythropoietin to help make new red blood cells.Iron is an important part of your red blood cells and is needed to transport oxygen in the body. This is not a complete list of side effects and others may occur. 2 Protocol for Intravenous iron sucrose - Venofer 2.1 Dosage The total cumulative dose of Venofer should be calculated using the table below. You will be watched closely by your doctor for 30 minutes after each dose. You must check to make sure that it is safe for you to take Venofer with all of your drugs and health problems. Venofer Side Effects. Some people may also experience skin irritation from the adhesive tape and other medical equipment used during the procedure. Injectafer can cause low blood levels of phosphorus, which is a condition called hypophosphatemia. Injectafer helps to treat IDA by providing an iron infusion directly into your body. Is the ketogenic diet right for autoimmune conditions? This may be helped by giving the medication more slowly or at a lower dose. * Feraheme has a boxed warning for this side effect. generalized weakness. If you notice any changes to your normal blood pressure, call your doctor right away. You may also report side effects at https://www.fda.gov/medwatch. There may be drug take-back programs in your area. Consult the product instructions and your pharmacist for storage details. I hope you found answers and are feeling better now. Your healthcare provider will watch you closely for 30 minutes after each dose. Its not known whether its safe to breastfeed while youre taking Injectafer. One study of just under 5000 HRT users found that 43% were affected. (A generic drug is an exact copy of the active drug in a brand-name medication.) But so far I feel better than before the infusion. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Reactions around the injection/infusion site, such as pain, irritation, itching, bleeding, or discoloration after leakage of injection into the skin. However, there has been a report of delayed allergic reaction in someone receiving a second dose of Injectafer. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Venofer only for the indication prescribed. Keep all drugs in a safe place. The body cannot metabolize such a high dose fast enough, so it ends up affecting a part of the body it wasnt intended to, such as the stomach. It can be given as a slow injection over 2 to 5 minutes or as an infusion. SIDE EFFECTS: In adult patients, the most common side effects (2%) include diarrhea, upset stomach, throwing up, headache, dizziness, hypotension, pruritus (itching), pain in extremity, arthralgia (joint pain), back pain, muscle cramp, injection site reactions, chest pain and peripheral edema (swelling). Your doctor will go over your On the other hand, some people may have a poor appetite that goes away when their anemia is treated. Tell your doctor if you are taking iron supplements or other iron-based oral medications. Reblozyl is a brand-name prescription medication used to treat anemia in certain blood disorders. If you have questions about side effects, call your doctor. Its not known if Injectafer is safe to take during pregnancy. With a delayed reaction, your body reacts to a drug that youve been exposed to in the past without having a reaction. Also tell them about any vitamins, herbs, and supplements you use. Injectafer contains the active drug ferric carboxymaltose. This is not a complete list of side effects and others may occur. Maximum concentrations of Injectafer are achieved within 15 minutes to 1.21 hours following administration. Learn more about the types of tests and treatment. These people may lose weight as their anemia improves because theyre more active. This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. Common side effects may include: fever, cold or flu symptoms ( sore throat, cough, stuffy nose, sneezing); high or low blood pressure; headache, dizziness; nausea, vomiting; diarrhea; Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: All drugs may cause side effects. Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox, Treating Opioid Use Disorder With Medications, Constipated? In stock alternatives of Venofer (based on Iron Sucrose ) Orofer S 200 Injection 1 Injection in 1 Packet 540 569 5% off. These are not all the side effects that may occur; contact your healthcare provider if you have questions. Consult your pharmacist or local waste disposal company. Hypophosphatemia has been reported in people using Injectafer after the drug was released onto the market. Allergic reactions typically occur the first time your body is exposed to a drug. Before you receive Venofer, tell your doctor if you have low blood pressure, hepatitis, or if you have received many blood transfusions in the past. If youre sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while youre taking Injectafer. Venofer (iron sucrose) is given as an injection into the veins (intravenously or IV) by a trained healthcare provider. (For more information on Venofer, see the Injectafer vs. Venofer section above). Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. }|54U|O~?|_v;f\o^(W+/-|^)O65_)rd sm }[x[)y.z Wz?9_jV0ub,`g`s?oXOSp/Kgw$b!Vb$;IvBVR9n|\0ln=;/=,mgw@do,[";/8nJL{n}Bb-|^6[~>a_1H'^M:^vv=iM+x|+Y intense abdominal pain. Phosphorus is an electrolyte that your body needs in order to make energy. However, Injectafer has been studied for use in children with iron deficiency anemia (IDA). There are different types of anemia, but IDA is the most common type. Examples of these side effects include dizziness and nausea. There may be risks to the mother and fetus associated with untreated IDA in pregnancy. Which tests can diagnose iron deficiency anemia? There have also been reports of serious allergic reactions to Venofer. But in some people, Injectafer can cause symptoms of hypophosphatemia to occur. You should not receive Venofer if you have known allergies to iron sucrose. (IV iron is absorbed by the body more rapidly than oral iron.) These side effects can range from being mild to severe. The signs and symptoms of anaphylaxis include dizziness or fainting, skin flushing and itchiness, difficulty breathing, rapid heart rate, low blood pressure and sudden anxiety.